Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30136929 | 0.79 | DPP4 (0.42) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL7089917 | 0.79 | DPP4 (0.42) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL2092773 | 0.78 | ALDH1A1 (0.41) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL13137274 | 0.77 | PRPS1 (0.44) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL29518340 | 0.77 | DPP4 (0.40) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL22704842 | 0.77 | DPP4 (0.40) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL22025920 | 0.75 | DPP4 (0.39) | DPP4TSHRALDH1A1KDM4EGLA | |
| SCHEMBL358722 | 0.74 | DPP4 (0.44) | DPP4TSHRALDH1A1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL6118670 | 0.73 | DPP4 (0.43) | DPP4TSHRALDH1A1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL15093741 | 0.73 | DPP4 (0.43) | DPP4TSHRALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3656769-A1 | ARYL-PHOSPHORUS-OXYGEN COMPOUND AS EGFR KINASE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-05-27 | — | — | EP | disclosed |
| EP-0944604-B1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20020128481-A1 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists | CUPPS THOMAS LEE (US) | 2002-09-12 | — | — | US | disclosed |
| US-6391878-B2 | COMPOUNDS SUCH AS (4,7-DIMETHYLBENZIMIDAZOL-5-YL)GUANIDINE; TREATING NASAL CONGESTION, OTITIS MEDIA, ASTHMA, PAIN, MIGRAINE, GASTROINTESTINAL DISORDER, ULCER | THE PROCTER & GAMBLE COMPANY | 2002-05-21 | — | — | US | disclosed |
| US-6225331-B1 | FOR THERAPY AND PROPHYLAXIS NASAL CONGESTION, OTITIS MEDIA, AND SINUSITIS, TREATING COUGH, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND/OR ASTHMA, BENIGN PROSTATIC HYPERTROPHY, CARDIOVASCULAR DISORDERS, GLAUCOMA, HYPEREMIA, CONJUNCTIVITIS | THE PROCTER & GAMBLE COMPANY | 2001-05-01 | — | — | US | disclosed |
| US-20010000345-A1 | Compounds such as (4,7-dimethylbenzimidazol-5-yl)guanidine; treating nasal congestion, otitis media, asthma, pain, migraine, gastrointestinal disorder, ulcer | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2001-04-19 | — | — | US | disclosed |
| EP-0944604-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023596-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |
| US-5691370-A | 5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2-adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0736022-A1 | 5-(2-IMIDAZOLINYLAMINO)BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5541210-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIHISTAMINES OR COUGH MEDICINE | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5478858-A | Respiratory system disorders, gastrointestinal disorders | THE PROCTER & GAMBLE COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| WO-1995016685-A1 | 5-(2-IMIDAZOLINYLAMINO)BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000345-A1 | Compounds such as (4,7-dimethylbenzimidazol-5-yl)guanidine; treating nasal congestion, otitis media, asthma, pain, migraine, gastrointestinal disorder, ulcer | ADRB2, ADRA2C, ADRA2B | DPP4 896/4885TSHR 1765/4885ALDH1A1 1083/4885 |
| US-20020128481-A1 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists | ADRB2, ADRA2C, ADRA2A | DPP4 1773/4885TSHR 673/4885ALDH1A1 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.