Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PBK | Q96KB5 | 4/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143538 | 0.82 | HRH3 (0.65) | TSHRHRH3ALDH1A1MAPTLMNA | |
| SCHEMBL6142865 | 0.81 | S1PR5 (0.41) | HRH3MAPTLMNAS1PR5MEN1 | |
| SCHEMBL6109481 | 0.78 | HRH3 (0.66) | TSHRHRH3ALDH1A1MAPTLMNA | |
| SCHEMBL6142844 | 0.70 | HTR6 (0.43) | HRH3MAPTLMNAS1PR5MEN1 | |
| SCHEMBL6143897 | 0.64 | GPR119 (0.47) | TSHRHRH3MAPT | |
| SCHEMBL6143807 | 0.64 | GPR119 (0.49) | HRH3 | |
| SCHEMBL7786542 | 0.64 | KCNA3 (0.44) | HRH3KMT2ANPY1R | |
| SCHEMBL30734529 | 0.63 | NPY1R (0.45) | HRH3KMT2ANPY1R | |
| SCHEMBL30735500 | 0.63 | NPY1R (0.45) | HRH3KMT2ANPY1R | |
| SCHEMBL7070092 | 0.63 | S1PR5 (0.42) | HRH3S1PR5NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |