Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8054441 | 0.95 | CA4 (0.39) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL119019 | 0.94 | — | — | |
| Bicarbonate SCHEMBL437197 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL293138 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9576852 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL28207811 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL26654550 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL4949748 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL15189590 | 0.91 | CA4 (0.36) | CA4CA1FAHD1 | |
| Bicarbonate SCHEMBL1679609 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 822 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496899-B1 | USE OF MATERIALS HAVING ZINC IONOPHORIC BEHAVIOR | PROCTER & GAMBLE (US) | 2021-06-23 | — | — | EP | claimed |
| EP-1603521-B1 | AUGMENTATION OF PYRITHIONE ACTIVITY OR A POLYVALENT METAL SALT OF PYRITHIONE ACTIVITY BY ZINC-CONTAINING LAYERED MATERIAL | PROCTER & GAMBLE (US) | 2020-06-17 | — | — | EP | claimed |
| EP-2763653-B1 | PERSONAL CARE COMPOSITIONS AND METHODS OF MAKING SAME | PROCTER & GAMBLE (US) | 2019-07-17 | — | — | EP | claimed |
| EP-2999455-B1 | METHOD OF ACHIEVING IMPROVED PRODUCT RHEOLOGY, COSMETIC CONSUMER ACCEPTANCE AND DEPOSITION | PROCTER & GAMBLE (US) | 2019-05-15 | — | — | EP | claimed |
| EP-2953686-B1 | HAIR CARE COMPOSITION COMPRISING CATIONIC POLYMERS AND ANIONIC PARTICULATES | PROCTER & GAMBLE (US) | 2019-03-27 | — | — | EP | claimed |
| CN-105338953-B | Method for achieving improved product rheology, cosmetic consumer acceptance and deposition | 宝洁公司 | 2018-09-28 | — | — | CN | claimed |
| US-9662291-B2 | Method of achieving improved hair feel | THE PROCTER & GAMBLE COMPANY (US) | 2017-05-30 | — | — | US | claimed |
| US-9381148-B2 | Composition comprising particulate zinc material with a high relative zinc lability | THE PROCTER & GAMBLE COMPANY (US) | 2016-07-05 | — | — | US | claimed |
| US-9381382-B2 | Composition comprising a particulate zinc material, a pyrithione or a polyvalent metal salt of a pyrithione and a gel network | THE PROCTER & GAMBLE COMPANY (US) | 2016-07-05 | — | — | US | claimed |
| US-20160143835-A1 | METHOD OF ACHIEVING IMPROVED HAIR FEEL | PROCTER & GAMBLE (US) | 2016-05-26 | — | — | US | claimed |
| US-20040191331-A1 | Composition comprising particulate zinc materials having a defined crystallite size | THE PROCTER & GAMBLE COMPANY | 2004-09-30 | — | — | US | claimed |
| WO-2004082649-A1 | AUGMENTATION OF PYRITHIONE ACTIVITY OR A POLYVALENT METAL SALT OF PYRITHIONE ACTIVITY BY ZINC-CONTAINING LAYERED MATERIAL | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-30 | — | — | WO | claimed |
| WO-2004082648-A1 | COMPOSITION COMPRISING PARTICULATE ZINC MATERIALS HAVING A DEFINED CRYSTALLITE SIZE | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-30 | — | — | WO | claimed |
| EP-1412284-A2 | COMPOSITION FOR TREATING CELLS AND METHODS FOR QUALITATIVELY AND QUANTITATIVELY CUSTOMIZING THE FORMULATION THEREOF FOR A HEURISTICALLY DERIVED LIVING CELL NUTRIENT-COMPOSITION-ON-DEMAND | Runkis, Walter H. (US) | 2004-04-28 | — | — | EP | claimed |
| US-20040058855-A1 | Use of materials having zinc ionophoric behavior | THE PROCTOR & GAMBLE COMPANY | 2004-03-25 | — | — | US | claimed |
| US-20030215522-A1 | Personal care compositions comprising a zinc containing material in an aqueous surfactant composition | THE PROCTER & GAMBLE COMPANY | 2003-11-20 | — | — | US | claimed |
| WO-2003088965-A1 | USE OF MATERIALS HAVING ZINC IONOPHORIC BEHAVIOR | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-30 | — | — | WO | claimed |
| WO-2003088957-A1 | PERSONAL CARE COMPOSITIONS COMPRISING A ZINC CONTAINING MATERIAL IN AN AQUEOUS SURFACTANT COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-30 | — | — | WO | claimed |
| US-20030073580-A1 | Composition for treating cells and method for qualitatively and quantitatively customizing the formulation thereof | RUNKIS WALTER H (US) | 2003-04-17 | — | — | US | claimed |
| WO-2002100772-A2 | COMPOSITION AND METHOD FOR TREATING CELLS AND PLANTS | RUNKIS WALTER H (US) | 2002-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058855-A1 | Use of materials having zinc ionophoric behavior | SLC30A6, SLC39A7, SLC30A7 | CA4 1751/4885CA1 1670/4885FAHD1 1144/4885 |
| US-20040191331-A1 | Composition comprising particulate zinc materials having a defined crystallite size | PPOX, LPO, THOC2 | CA4 1164/4885CA1 283/4885FAHD1 1499/4885 |
| US-20030215522-A1 | Personal care compositions comprising a zinc containing material in an aqueous surfactant composition | SLC30A7, SLC39A7, SOD1 | CA4 1668/4885CA1 1035/4885FAHD1 3592/4885 |
| US-20160143835-A1 | METHOD OF ACHIEVING IMPROVED HAIR FEEL | POLR1C, PMP22, SUCLG1 | CA4 996/4885CA1 922/4885FAHD1 1221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.