Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.34 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153 | 0.90 | GAA (0.36) | LPAR1LPAR2LPAR3AOC3ABCC3 | |
| SCHEMBL7294 | 0.88 | P2RX7 (0.36) | LPAR1LPAR2LPAR3FFAR4P2RX7 | |
| SCHEMBL2214 | 0.88 | LPAR1 (0.45) | LPAR1LPAR2LPAR3AOC3ABCC3 | |
| SCHEMBL7148 | 0.87 | ALDH1A1 (0.38) | LPAR1LPAR2LPAR3AOC3FFAR4 | |
| SCHEMBL6150 | 0.86 | BRD4 (0.36) | AOC3FFAR4ALDH1A1BRD4TAAR1 | |
| SCHEMBL7534 | 0.85 | L3MBTL1 (0.34) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1559 | 0.84 | RAB9A (0.39) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7297 | 0.82 | SCD5 (0.35) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6916 | 0.82 | BRD4 (0.33) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6613 | 0.82 | FFAR4 (0.35) | LPAR1AOC3FFAR4ALOX5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |