Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | DTYMK | P23919 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981893 | 0.92 | GAA (0.56) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL8567338 | 0.89 | GPR119 (0.48) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL28708137 | 0.88 | GPR119 (0.49) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL110163 | 0.88 | NCF1 (0.51) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL670559 | 0.87 | ACHE (0.48) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL615082 | 0.86 | GPR119 (0.48) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL7986047 | 0.86 | CKS1B (0.57) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL8566291 | 0.85 | ACHE (0.47) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL19297053 | 0.85 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3ACHE | |
| SCHEMBL4511470 | 0.85 | GPR119 (0.50) | CHRM2CHRM4CHRM1CHRM3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299338-B | (2-benzylphenyl) piperazine derivatives and uses thereof | 广东东阳光药业有限公司 | 2021-09-28 | — | — | CN | disclosed |
| US-9951074-B2 | Dihydropteridinone derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170145013-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-9012460-B2 | 1-(2-phenoxymethylphenyl)piperazine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-9012460-B2 | 1-(2-phenoxymethylphenyl)piperazine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-9012460-B2 | 1-(2-phenoxymethylphenyl)piperazine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-20140288089-A1 | 1-(2-PHENOXYMETHYLPHENYL)PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288089-A1 | 1-(2-PHENOXYMETHYLPHENYL)PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288089-A1 | 1-(2-PHENOXYMETHYLPHENYL)PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-09-25 | — | — | US | disclosed |
| US-8778949-B2 | 1-(2-phenoxymethylphenyl)piperazine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-07-15 | — | — | US | disclosed |
| US-20070027163-A1 | Indol-3-y-carbonyl-piperidin and piperazin-derivatives | HOFFMANN-LA ROCHE INC. | 2007-02-01 | — | — | US | disclosed |
| EP-1368340-B1 | PIPERAZINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2005-08-10 | — | — | EP | disclosed |
| US-20040092507-A1 | Melanocortin receptor agonists | ELI LILLY AND COMPANY | 2004-05-13 | — | — | US | disclosed |
| EP-1368340-A1 | PIPERAZINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002059108-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |
| WO-1998025617-A1 | SUBSTITUTED ARYL PIPERAZINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0783498-A4 | SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS | MERCK & CO INC (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0783498-A1 | SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5607936-A | USEFUL IN TREATMENT OF RESPIRATORY DISEASES | MERCK & CO., INC. (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996010568-A1 | SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1996-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092507-A1 | Melanocortin receptor agonists | MC1R, MC4R, MC5R | CHRM2 348/4885CHRM4 331/4885CHRM1 251/4885 |
| US-20070027163-A1 | Indol-3-y-carbonyl-piperidin and piperazin-derivatives | AVPR1A, AVPR2, OXTR | CHRM2 668/4885CHRM4 1856/4885CHRM1 251/4885 |
| US-20140288089-A1 | 1-(2-PHENOXYMETHYLPHENYL)PIPERAZINE COMPOUNDS | SLC6A2, SLC6A4, TPH1 | CHRM2 84/4885CHRM4 269/4885CHRM1 47/4885 |
| US-20170145013-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BRD3 | CHRM2 2932/4885CHRM4 3744/4885CHRM1 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.