Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153010 | 0.92 | POLB (0.46) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6153623 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2HRH3HTT | |
| SCHEMBL6152949 | 0.79 | PLAAT3 (0.35) | MAPT | |
| SCHEMBL6152322 | 0.77 | LTA4H (0.51) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6152350 | 0.77 | HPGD (0.39) | L3MBTL1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL6152608 | 0.72 | CYP4F2 (0.54) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6153126 | 0.71 | L3MBTL1 (0.43) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6152429 | 0.67 | ALDH1A1 (0.53) | L3MBTL1KDM4EKMT2AALDH1A1MAPT | |
| SCHEMBL6153062 | 0.66 | HPGD (0.34) | L3MBTL1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL6152414 | 0.66 | PTAFR (0.37) | L3MBTL1KDM4EMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |