SCHEMBL6154744

SCHEMBL6154744

C=Cc1cc(OCOCC)cc(OCOCC)c1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.39
AHR P35869 2/20 0.39
CHRNB2 P17787 2/20 0.38
CHRNB4 P30926 2/20 0.38
CHRNA3 P32297 2/20 0.38
CHRNA7 P36544 2/20 0.38
CHRNA4 P43681 2/20 0.38
NQO1 P15559 1/20 0.33
PTPN1 P18031 1/20 0.33
CHRNA10 Q9GZZ6 1/20 0.32
CHRNA9 Q9UGM1 1/20 0.32
RELA Q04206 1/20 0.32
ABL1 P00519 1/20 0.30
ABCB1 P08183 1/20 0.30
BCR P11274 1/20 0.30
CYP1A1 P04798 1/20 0.30
CYP1B1 Q16678 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6197489 0.84 ESR1 (0.47) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL8751920 0.83 NQO1 (0.46) ESR1AHRNQO1PTPN1RELA
SCHEMBL1796680 0.82 CHRNA7 (0.54) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL7639908 0.82 KDM4E (0.44) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL22454156 0.81 CHRNB2 (0.39) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL6156345 0.81 ALDH1A1 (0.39) ESR1AHRNQO1PTPN1
SCHEMBL283041 0.78 CHRNA7 (0.43) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL27786572 0.77 ESR1 (0.59) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL16954499 0.77 ESR1 (0.59) ESR1AHRCHRNB2CHRNB4CHRNA3
SCHEMBL16101859 0.75 NQO1 (0.39) ESR1AHRNQO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP disclosed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US disclosed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 EP disclosed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 WO disclosed