Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9224574 | 0.78 | ALDH1A1 (0.48) | MEN1KMT2ASIRT1NPC1RAB9A | |
| SCHEMBL2668067 | 0.78 | HPGD (0.52) | KCNA5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12305723 | 0.76 | MEN1 (0.43) | KCNA5KCNA3MEN1KMT2AL3MBTL1 | |
| SCHEMBL6264342 | 0.76 | HPGD (0.49) | SLC6A5MEN1KMT2AL3MBTL1 | |
| SCHEMBL12305557 | 0.75 | ESRRG (0.43) | MEN1KMT2ASIRT1NPC1RAB9A | |
| SCHEMBL1300262 | 0.75 | MAPT (0.52) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL21820359 | 0.73 | RAB9A (0.46) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL6156056 | 0.73 | SLC6A5 (0.47) | SLC6A5NPC1RAB9A | |
| SCHEMBL19051492 | 0.72 | KMT2A (0.56) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL17481130 | 0.71 | HDAC2 (0.49) | MEN1KMT2ANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597245-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | AstraZeneca AB (SE) | 2005-11-23 | — | — | EP | disclosed |
| EP-1501813-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004076430-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-09-10 | — | — | WO | disclosed |
| WO-2003091232-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | WO | disclosed |