Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797 | 0.87 | EPHX2 (0.53) | LTA4HFFAR1CYP4F2CYP4A11FFAR4 | |
| SCHEMBL5811 | 0.85 | MMP2 (0.54) | LTA4HFFAR1CYP4F2CYP4A11MMP2 | |
| SCHEMBL6212 | 0.85 | MAOB (0.54) | FFAR1MMP2MMP9FFAR4ADAMTS4 | |
| SCHEMBL6073 | 0.81 | L3MBTL1 (0.56) | LTA4HFFAR1CYP4F2CYP4A11MMP1 | |
| SCHEMBL11898793 | 0.81 | CYP4F2 (0.51) | LTA4HCYP4F2CYP4A11NPC1RAB9A | |
| SCHEMBL11899994 | 0.80 | LTA4H (0.61) | LTA4HFFAR1 | |
| SCHEMBL5636 | 0.77 | MMP2 (0.56) | LTA4HFFAR1CYP4F2CYP4A11MMP2 | |
| SCHEMBL12049 | 0.77 | LTA4H (0.50) | LTA4HFFAR1CYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL10689 | 0.76 | CYSLTR1 (0.66) | FFAR1 | |
| SCHEMBL6109 | 0.75 | ADAM17 (0.54) | LTA4HFFAR1CYP4F2CYP4A11MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |