Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575622 | 1.00 | ADRB2 (0.50) | ADRB2LOXL2HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL6159994 | 0.99 | ADRB2 (0.49) | ADRB2LOXL2HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL6575932 | 0.99 | ADRB2 (0.49) | ADRB2LOXL2HDAC3HDAC4HDAC1 | |
| SCHEMBL7606159 | 0.83 | LOXL2 (0.55) | ADRB2LOXL2TPH1ALDH1A1SLC6A3 | |
| SCHEMBL7606167 | 0.83 | LOXL2 (0.55) | ADRB2LOXL2TPH1ALDH1A1SLC6A3 | |
| SCHEMBL7120060 | 0.81 | ALDH1A1 (0.44) | ADRB2LOXL2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL7057465 | 0.80 | ADRB2 (0.46) | ADRB2LOXL2HDAC1HDAC6LTA4H | |
| Hydrochloric Acid SCHEMBL7120057 | 0.80 | ALDH1A1 (0.43) | ADRB2LOXL2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2291027 | 0.80 | LTA4H (0.51) | LOXL2LTA4HTPH1FFAR1PDPK1 | |
| SCHEMBL2291017 | 0.80 | LTA4H (0.51) | LOXL2LTA4HTPH1FFAR1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| EP-1474405-A2 | PROCESS FOR THE PREPARATION OF 4-HETERO-SUBSTITUTED PHENYLALANINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-11-10 | — | — | EP | disclosed |
| EP-0983217-B1 | METHOD FOR REMOVING HEAVY METALS FROM ORGANIC COMPOUNDS | ZAMBON SPA (IT) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003068725-A2 | PROCESS FOR THE PREPARATION OF 4-HETERO-SUBSTITUTED PHENYLALANINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
| US-6448408-B1 | CHEMICAL INTERMEDIATES IN PREPARATION OF N-MERCAPTOACYL DERIVATIVE OF PHENYLALANINE WITH PHARMALOGICAL ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2002-09-10 | — | — | US | disclosed |
| US-20020028946-A1 | PROCESS FOR THE PREPARATION OF HETEROARYL-PHENYLALANINES | ZAMBON GROUP S.P.A. (IT) | 2002-03-07 | — | — | US | disclosed |
| CN-1071325-C | Thiol derivatives having metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 2001-09-19 | — | — | CN | disclosed |
| EP-0948492-B1 | PROCESS FOR THE PREPARATION OF HETEROARYL-PHENYLALANINES | ZAMBON SPA (IT) | 2001-07-11 | — | — | EP | disclosed |
| US-6177571-B1 | REMOVING HEAVY METALS, SELECTED FROM PALLADIUM, TIN AND NICKEL, FROM HEAVY METAL COMPLEXES WITH THIAZOLE COMPOUNDS IN AQUEOUS OR ALCOHOLIC SOLUTION, BY PRECIPITATION AS SULFIDES | ZAMBON GROUP S.P.A. (IT) | 2001-01-23 | — | — | US | disclosed |
| EP-0983217-A1 | METHOD FOR REMOVING HEAVY METALS FROM ORGANIC COMPOUNDS | ZAMBON GROUP S.p.A. (IT) | 2000-03-08 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| EP-0948492-A1 | PROCESS FOR THE PREPARATION OF HETEROARYL-PHENYLALANINES | ZAMBON GROUP S.p.A. (IT) | 1999-10-13 | — | — | EP | disclosed |
| CN-1206411-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 1999-01-27 | — | — | CN | disclosed |
| WO-1998051647-A1 | METHOD FOR REMOVING HEAVY METALS FROM ORGANIC COMPOUNDS | ZAMBON GROUP S.P.A. (IT) | 1998-11-19 | — | — | WO | disclosed |
| EP-0877740-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1998-11-18 | — | — | EP | disclosed |
| WO-1998028284-A1 | PROCESS FOR THE PREPARATION OF HETEROARYL-PHENYLALANINES | ZAMBON GROUP S.P.A. (IT) | 1998-07-02 | — | — | WO | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |
| WO-1997024342-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1997-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028946-A1 | PROCESS FOR THE PREPARATION OF HETEROARYL-PHENYLALANINES | PAH, TYR, CYP2S1 | ADRB2 219/4885LOXL2 2239/4885HDAC3 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.