Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 9/20 | 0.54 |
| ▸ | DRD3 | P35462 | 9/20 | 0.54 |
| ▸ | AKT1 | P31749 | 3/20 | 0.53 |
| ▸ | AKT2 | P31751 | 2/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7586080 | 0.86 | CCR5 (0.67) | DRD4ALDH1A1DRD2DRD3AKT1 | |
| SCHEMBL6593749 | 0.84 | OPRM1 (0.53) | DRD4ALDH1A1DRD2DRD3AKT1 | |
| SCHEMBL6161107 | 0.83 | OPRL1 (0.52) | DRD4ALDH1A1DRD2DRD3AKT1 | |
| SCHEMBL11716653 | 0.83 | OPRM1 (0.52) | DRD4ALDH1A1DRD2DRD3AKT1 | |
| SCHEMBL11794420 | 0.83 | OPRM1 (0.52) | DRD4ALDH1A1DRD2DRD3AKT1 | |
| SCHEMBL28236159 | 0.79 | CYP11B2 (0.63) | CYP11B2OPRM1OPRL1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL11792992 | 0.79 | LMNA (0.52) | DRD4DRD2DRD3AKT1AKT2 | |
| SCHEMBL6596916 | 0.77 | OPRD1 (0.59) | LMNATSHROPRM1OPRL1OPRK1 | |
| SCHEMBL6161817 | 0.77 | CYP11B2 (0.60) | PDE6DALDH1A1ALDH2ALDH3A1CYP11B2 | |
| SCHEMBL16127791 | 0.76 | OPRM1 (0.55) | DRD4DRD2DRD3AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |