Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159833 | 0.83 | CASP1 (0.54) | CASP1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL6157827 | 0.83 | CASP1 (0.43) | CASP1KMT2AMEN1HPGD | |
| SCHEMBL6161964 | 0.81 | CASP1 (0.54) | CASP1KMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL6157421 | 0.80 | CASP1 (0.41) | CASP1KMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL6158761 | 0.80 | CASP1 (0.38) | CASP1KMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL7487986 | 0.80 | CASP1 (0.55) | CASP1SMN1; SMN2GAA | |
| SCHEMBL6157558 | 0.80 | KMT2A (0.48) | CASP1KMT2ALMNAHPGD | |
| SCHEMBL6157985 | 0.79 | CASP3 (0.41) | CASP1 | |
| SCHEMBL6160437 | 0.79 | CASP1 (0.52) | CASP1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL6157870 | 0.76 | CASP1 (0.56) | CASP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |