Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.52 |
| ▸ | CASP3 | P42574 | 9/20 | 0.47 |
| ▸ | CASP7 | P55210 | 8/20 | 0.47 |
| ▸ | CASP6 | P55212 | 7/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 7/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157827 | 0.87 | CASP1 (0.43) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6157985 | 0.86 | CASP3 (0.41) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6157558 | 0.85 | KMT2A (0.48) | CASP1MTNR1AMTNR1B | |
| SCHEMBL6161964 | 0.80 | CASP1 (0.54) | CASP1SMN1; SMN2NPC1RAB9AMTNR1A | |
| SCHEMBL6159833 | 0.79 | CASP1 (0.54) | CASP1KDM4EMTNR1A | |
| SCHEMBL6161919 | 0.79 | CASP1 (0.47) | CASP1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL6158761 | 0.79 | CASP1 (0.38) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6159212 | 0.78 | CASP1 (0.55) | CASP1KDM4ESMN1; SMN2 | |
| SCHEMBL6158900 | 0.75 | CASP1 (0.38) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6160192 | 0.75 | CASP3 (0.33) | CASP1CASP3CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |