Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21881381 | 1.00 | PPARA (0.47) | PPARAPPARGPOLBALDH1A1KDM4E | |
| SCHEMBL4968147 | 0.84 | ALOX5 (0.44) | PPARAPPARGPOLBALDH1A1KDM4E | |
| SCHEMBL3740253 | 0.76 | KMT2A (0.51) | PPARAPPARGALDH1A1KDM4ECYP2C19 | |
| SCHEMBL4560908 | 0.76 | SLC1A3 (0.44) | PPARAPPARGPOLBALDH1A1KDM4E | |
| SCHEMBL7080315 | 0.76 | CYP2C19 (0.42) | PPARAPPARGPOLBALDH1A1KDM4E | |
| SCHEMBL660871 | 0.75 | KDM4E (0.55) | PPARAPPARGALDH1A1KDM4ECYP2D6 | |
| SCHEMBL21881586 | 0.75 | KDM4E (0.55) | PPARAPPARGALDH1A1KDM4ECYP2D6 | |
| SCHEMBL13324879 | 0.75 | KDM4E (0.55) | PPARAPPARGALDH1A1KDM4ECYP2D6 | |
| SCHEMBL8207520 | 0.74 | L3MBTL1 (0.50) | POLBALDH1A1CYP2D6CYP2C19LMNA | |
| SCHEMBL11084533 | 0.73 | SMN1; SMN2 (0.42) | PPARAPPARGALDH1A1KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109893528-B | Use of koumine for treating lipid metabolism disorder and related diseases or symptoms thereof | 福建医科大学 | 2022-12-06 | — | — | CN | disclosed |
| CN-105963676-B | Agonists of guanylate cyclase for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstones, obesity and other cardiovascular diseases | 药物协和股份有限公司 | 2020-02-18 | — | — | CN | disclosed |
| CN-102858361-B | Agonists of guanylate cyclase for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstones, obesity and other cardiovascular diseases | 药物协和股份有限公司 | 2016-08-03 | — | — | CN | disclosed |
| EP-1305301-B1 | ALPHA-ACYL AND ALPHA-HETEROATOM-SUBSTITUTED BENZENE ACETAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-06-15 | — | — | EP | disclosed |
| US-4276294-A | ANTICONVULSANTS | CIBA-GEIGY CORPORATION (US) | 1981-06-30 | — | — | US | disclosed |