Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162587 | 0.83 | KDM4E (0.47) | TSHRKDM4E | |
| SCHEMBL3892463 | 0.78 | CHRNA7 (0.72) | CHRNA7TSHRDRD4DRD2DRD3 | |
| SCHEMBL16783935 | 0.77 | CACNA1G (0.69) | TSHRUSP2DRD4CACNA1GL3MBTL1 | |
| SCHEMBL16783991 | 0.77 | CACNA1G (0.69) | TSHRUSP2DRD4CACNA1GL3MBTL1 | |
| SCHEMBL16783934 | 0.77 | CACNA1G (0.69) | TSHRUSP2DRD4CACNA1GL3MBTL1 | |
| SCHEMBL8220682 | 0.76 | TSHR (0.60) | TSHRUSP2DRD4DRD2DRD3 | |
| SCHEMBL11741470 | 0.76 | ACE2 (0.72) | TSHRUSP2PRMT5WDR77CACNA1G | |
| SCHEMBL6159875 | 0.74 | HTR2A (0.54) | DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL9750973 | 0.74 | L3MBTL1 (0.74) | CHRNA7TSHRDRD4DRD2DRD3 | |
| SCHEMBL6160819 | 0.73 | DRD2 (0.55) | DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |