Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 2/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | CPA3 | P15088 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28711269 | 0.90 | KMT2A (0.42) | HPGDALDH1A1POLBKMT2ACYP3A4 | |
| SCHEMBL28711268 | 0.90 | KMT2A (0.42) | HPGDALDH1A1POLBKMT2ACYP3A4 | |
| SCHEMBL24986138 | 0.85 | ROCK2 (0.47) | HPGDALDH1A1KMT2ACYP3A4HIF1A | |
| SCHEMBL28712598 | 0.85 | ROCK2 (0.47) | HPGDALDH1A1KMT2ACYP3A4HIF1A | |
| SCHEMBL1818244 | 0.84 | TSHR (0.43) | HPGDALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL11404152 | 0.83 | EGFR (0.45) | ALDH1A1LMNAPOLBKMT2ANPC1 | |
| SCHEMBL18325693 | 0.81 | HPGD (0.66) | HPGDALDH1A1LMNACYP1A2KMT2A | |
| SCHEMBL616619 | 0.81 | HPGD (0.49) | HPGDALDH1A1LMNACYP1A2POLB | |
| SCHEMBL16669849 | 0.80 | ALPI (0.58) | HPGDALDH1A1LMNALTA4HALPI | |
| SCHEMBL616294 | 0.80 | ALDH1A1 (0.54) | HPGDALDH1A1LMNACYP1A2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-07-01 | — | — | US | disclosed |
| US-10745390-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-08-18 | — | — | US | disclosed |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-11-23 | — | — | US | disclosed |
| US-9695157-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-07-30 | — | — | US | disclosed |
| US-9000009-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-16 | — | — | US | disclosed |
| WO-2010068767-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | HPGD 280/4885ALDH1A1 1639/4885LMNA 3015/4885 |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | HPGD 280/4885ALDH1A1 1639/4885LMNA 3015/4885 |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | HPGD 274/4885ALDH1A1 1447/4885LMNA 2895/4885 |
| US-10745390-B2 | Small molecule activators of mitochondrial function | TFAM, TFB2M, GFM1 | HPGD 280/4885ALDH1A1 1639/4885LMNA 3015/4885 |
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | HPGD 280/4885ALDH1A1 1639/4885LMNA 3015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.