Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769850 | 0.88 | OPRM1 (0.38) | DHODHOPRM1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6776388 | 0.88 | OPRM1 (0.38) | DHODHOPRM1BUB1 | |
| SCHEMBL6770751 | 0.87 | OPRM1 (0.45) | DHODHOPRM1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6770575 | 0.85 | GPBAR1 (0.39) | DHODHOPRM1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6168332 | 0.85 | ALDH1A1 (0.47) | DHODHOPRM1BUB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6167296 | 0.85 | HIF1A (0.47) | DHODHOPRM1BRD4HIF1AALDH1A1 | |
| SCHEMBL6164547 | 0.84 | DHODH (0.43) | DHODHBUB1RIPK1BRD4HIF1A | |
| SCHEMBL6168193 | 0.83 | ABCG2 (0.42) | OPRM1BUB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6164978 | 0.81 | DHODH (0.41) | DHODHBUB1RIPK1BRD4HIF1A | |
| SCHEMBL6162163 | 0.81 | DHODH (0.41) | DHODHBUB1RIPK1BRD4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |