Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6166889 | 0.99 | CHRM3 (0.49) | CHRM3OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL6168102 | 0.94 | CHRM3 (0.42) | CHRM3OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL8569662 | 0.86 | PARP1 (0.49) | CHRM3PARP1 | |
| Hydrochloric Acid SCHEMBL6169543 | 0.85 | PARP1 (0.48) | CHRM3PARP1 | |
| SCHEMBL6168606 | 0.84 | OPRL1 (0.52) | CHRM3OPRL1OPRM1OPRK1DRD2 | |
| SCHEMBL8564971 | 0.84 | TACR1 (0.43) | OPRL1OPRM1OPRK1DRD2DRD4 | |
| SCHEMBL29445321 | 0.84 | OPRL1 (0.52) | CHRM3OPRL1OPRM1OPRK1DRD2 | |
| SCHEMBL8566631 | 0.84 | OPRM1 (0.49) | CHRM3OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL8565908 | 0.82 | TACR1 (0.41) | CHRM3OPRL1CCR5 | |
| SCHEMBL8567952 | 0.82 | SLC18A3 (0.49) | OPRL1OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122253-B1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6645971-B1 | Pollakiuria and urinary incontinence treatment; muscarinic receptor antagonists; anticholinergic, anticonvulsants, antiulcer, and antiasthmatics; Parkinson*s disease | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2003-11-11 | — | — | US | disclosed |
| EP-1122253-A1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-08-08 | — | — | EP | disclosed |
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |