Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565841 | 0.90 | CHRM3 (0.56) | OPRM1THRBHRH3CHRM3OPRL1 | |
| SCHEMBL6168606 | 0.89 | OPRL1 (0.52) | OPRM1CHRM3OPRL1CYP3A4MEN1 | |
| SCHEMBL29445321 | 0.89 | OPRL1 (0.52) | OPRM1CHRM3OPRL1CYP3A4MEN1 | |
| SCHEMBL8569508 | 0.87 | MEN1 (0.53) | OPRM1CHRM3OPRL1MEN1ALDH1A1 | |
| SCHEMBL6165994 | 0.85 | CHRM1 (0.48) | CHRM3OPRL1ALDH1A1 | |
| SCHEMBL8565096 | 0.84 | CCR5 (0.48) | KDM1ACHRM3OPRL1CYP3A4CCR5 | |
| SCHEMBL8570499 | 0.84 | CHRM3 (0.55) | OPRM1CHRM3MEN1ALDH1A1KMT2A | |
| SCHEMBL6168165 | 0.83 | CHRM3 (0.49) | OPRM1CHRM3OPRL1MEN1ALDH1A1 | |
| SCHEMBL8570369 | 0.83 | CHRM3 (0.50) | OPRM1CHRM3OPRL1MEN1KMT2A | |
| SCHEMBL8564971 | 0.82 | TACR1 (0.43) | OPRM1HRH3OPRL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122253-B1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6645971-B1 | Pollakiuria and urinary incontinence treatment; muscarinic receptor antagonists; anticholinergic, anticonvulsants, antiulcer, and antiasthmatics; Parkinson*s disease | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2003-11-11 | — | — | US | disclosed |
| EP-1122253-A1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-08-08 | — | — | EP | disclosed |