SCHEMBL6165832

SCHEMBL6165832

c1cncc(Cc2ncco2)c1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
HRH4 Q9H3N8 1/20 0.45
HRH3 Q9Y5N1 1/20 0.45
CYP1A2 P05177 4/20 0.44
CYP2D6 P10635 2/20 0.44
CHRNA7 P36544 1/20 0.43
MMP2 P08253 1/20 0.42
CHRNB2 P17787 2/20 0.42
CHRNA4 P43681 2/20 0.42
CYP2A6 P11509 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
TBXAS1 P24557 1/20 0.41
LTA4H P09960 1/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL527670 0.81 CALM1 (0.44) LTA4H
SCHEMBL6165634 0.77 S1PR1 (0.41) CYP11B1CYP11B2HRH4HRH3CYP1A2
Biphenyl SCHEMBL28708802 0.76 RAB9A (0.47)
SCHEMBL727185 0.76 CYP1A2 (0.62) CYP11B1CYP11B2HRH4HRH3CYP1A2
SCHEMBL25344450 0.74 L3MBTL1 (0.43)
SCHEMBL29457462 0.74 GABRP (0.42)
SCHEMBL25343559 0.74 GABRP (0.42)
SCHEMBL7704422 0.73 CYP1B1 (0.32)
SCHEMBL11184781 0.73 MAPK1 (0.48) HRH4HRH3CYP1A2CYP2D6CHRNA7
SCHEMBL20773636 0.72 IDO1 (0.40) CYP1A2CYP2D6CYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417177-A4 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL MYERS SQUIBB PHARMA CO (US) 2005-10-19 EP disclosed
EP-1417177-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003007883-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-01-30 WO disclosed
EP-1071668-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Du Pont Pharmaceuticals Company (US) 2001-01-31 EP disclosed
WO-1999054308-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS DU PONT PHARMACEUTICALS COMPANY (US) 1999-10-28 WO disclosed