Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330427 | 0.93 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2TSHRPDE4APDE4B | |
| SCHEMBL6167735 | 0.85 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2TSHRLMNAPKM | |
| SCHEMBL13841817 | 0.84 | KMT2A (0.64) | ALDH1A1SMN1; SMN2TSHRPDE4APDE4B | |
| SCHEMBL6167372 | 0.81 | KMT2A (0.60) | ALDH1A1SMN1; SMN2TSHRPDE4APDE4B | |
| SCHEMBL4035842 | 0.77 | PNMT (0.49) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL15682658 | 0.77 | KMT2A (0.64) | ALDH1A1SMN1; SMN2TSHRPDE4APDE4B | |
| SCHEMBL6331056 | 0.77 | KMT2A (0.57) | ALDH1A1SMN1; SMN2TSHRPDE4APDE4B | |
| SCHEMBL4040738 | 0.76 | NOTUM (0.47) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6168219 | 0.75 | HTR6 (0.54) | ALDH1A1SMN1; SMN2TSHRLMNAMEN1 | |
| SCHEMBL4765964 | 0.75 | HTR2C (0.64) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392316-B1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2005-04-20 | — | — | EP | disclosed |
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1392316-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089811-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | HTR6, HTR5A, HTR1A | ALDH1A1 1942/4885SMN1; SMN2 2084/4885TSHR 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.