Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.49 |
| ▸ | XDH | P47989 | 6/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168318 | 1.00 | MGLL (0.49) | MGLLXDHCTBP2DRD4SMN1; SMN2 | |
| SCHEMBL4586342 | 0.84 | ALDH1A1 (0.51) | MGLLXDHCTBP2DRD4SMN1; SMN2 | |
| SCHEMBL4586337 | 0.84 | ALDH1A1 (0.51) | MGLLXDHCTBP2DRD4SMN1; SMN2 | |
| SCHEMBL4586154 | 0.81 | CTSL (0.55) | MGLLXDHCTBP2SMN1; SMN2KDM4E | |
| SCHEMBL4586157 | 0.81 | CTSL (0.55) | MGLLXDHCTBP2SMN1; SMN2KDM4E | |
| SCHEMBL257218 | 0.81 | CTSL (0.55) | MGLLXDHCTBP2SMN1; SMN2KDM4E | |
| SCHEMBL28291535 | 0.80 | CTBP2 (0.51) | MGLLXDHCTBP2DRD4SMN1; SMN2 | |
| SCHEMBL6179567 | 0.79 | MGLL (0.50) | MGLLXDHCTBP2SMN1; SMN2KDM4E | |
| SCHEMBL6179568 | 0.79 | MGLL (0.50) | MGLLXDHCTBP2SMN1; SMN2KDM4E | |
| SCHEMBL6736924 | 0.78 | MGLL (0.46) | MGLLXDHCTBP2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |