Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426350 | 0.85 | NR1H2 (0.42) | NR1H2MAP2K4HSP90AA1HSP90AB1BRD4 | |
| SCHEMBL2304349 | 0.85 | ESR2 (0.43) | MAP2K4HSP90AA1HSP90AB1FAAHPOLB | |
| SCHEMBL12090381 | 0.85 | MAP2K4 (0.38) | MAP2K4HSP90AA1HSP90AB1FAAHPOLB | |
| SCHEMBL12491156 | 0.82 | FAAH (0.36) | NR1H2MAP2K4HSP90AA1HSP90AB1FAAH | |
| SCHEMBL7016168 | 0.81 | L3MBTL1 (0.44) | MAP2K4FAAHPOLBMEN1KMT2A | |
| SCHEMBL6369557 | 0.80 | MAP2K4 (0.50) | NR1H2MAP2K4RORCRETKDR | |
| SCHEMBL30833750 | 0.80 | MAP2K4 (0.39) | NR1H2MAP2K4HSP90AA1HSP90AB1FAAH | |
| SCHEMBL6170318 | 0.80 | MAPT (0.44) | BRD4GABRG2GABRB3GABRA5MEN1 | |
| SCHEMBL12999397 | 0.79 | NR1H2 (0.38) | NR1H2MAP2K4HSP90AA1HSP90AB1FAAH | |
| SCHEMBL6480204 | 0.79 | PDGFRA (0.46) | MAP2K4HSP90AA1HSP90AB1FAAHBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019045-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20030078431-A1 | Antithrombotic agents | BEIGHT DOUGLAS WADE (US) | 2003-04-24 | — | — | US | disclosed |
| US-6500851-B2 | ANTICOAGULANT IN MAMMLS | ELI LILLY AND COMPANY | 2002-12-31 | — | — | US | disclosed |
| US-20020173518-A1 | Antithrombotic agents | BEIGHT DOUGLAS WADE (US) | 2002-11-21 | — | — | US | disclosed |
| US-6372759-B1 | BLOOD COAGULATION FACTOR XA FOR MAMMALS | ELI LILLY AND COMPANY | 2002-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173518-A1 | Antithrombotic agents | SERPINC1, TFPI, F11 | NR1H2 751/4885MAP2K4 4678/4885HSP90AA1 2534/4885 |
| US-20030078431-A1 | Antithrombotic agents | SERPINC1, TFPI, F11 | NR1H2 751/4885MAP2K4 4678/4885HSP90AA1 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.