Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.42 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203734 | 0.85 | ALDH1A1 (0.55) | RAB9ANPC1L3MBTL1HDAC1HDAC6 | |
| SCHEMBL6283084 | 0.82 | RAB9A (0.56) | RAB9ANPC1L3MBTL1HDAC1HDAC6 | |
| SCHEMBL6775249 | 0.81 | NPC1 (0.62) | RAB9ANPC1L3MBTL1HDAC1HDAC6 | |
| SCHEMBL4102938 | 0.80 | L3MBTL1 (0.68) | RAB9ANPC1L3MBTL1MAPTCYP3A4 | |
| SCHEMBL2512740 | 0.80 | RAB9A (0.64) | RAB9ANPC1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL2645324 | 0.80 | LTA4H (0.58) | RAB9ANPC1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL7433779 | 0.80 | LMNA (0.58) | RAB9ANPC1L3MBTL1HDAC1HDAC6 | |
| SCHEMBL1157353 | 0.79 | ALDH1A1 (0.66) | L3MBTL1MAPTSRD5A2ALDH1A1PLOD2 | |
| SCHEMBL6283043 | 0.79 | KMT2A (0.57) | RAB9ANPC1L3MBTL1HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL5253545 | 0.79 | LTA4H (0.56) | RAB9ANPC1L3MBTL1MAPTSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |