Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7030607 | 0.81 | FLT3 (0.57) | HRH4HRH3PDGFRBFLT3ALDH1A1 | |
| SCHEMBL18900665 | 0.76 | FLT3 (0.59) | HRH4HRH3PDGFRBFLT3ALDH1A1 | |
| SCHEMBL30310328 | 0.75 | F7 (0.74) | HRH4ALOX15PDGFRBFLT3MEN1 | |
| SCHEMBL671001 | 0.75 | F7 (0.74) | HRH4ALOX15PDGFRBFLT3MEN1 | |
| SCHEMBL23835754 | 0.73 | ALOX15 (0.69) | HRH4ALOX15PDGFRBFLT3MEN1 | |
| SCHEMBL29062810 | 0.73 | ALOX15 (0.64) | HRH4ALOX15PDGFRBFLT3MEN1 | |
| SCHEMBL16842006 | 0.73 | TAS1R3 (0.59) | ALOX15F10PYGL | |
| SCHEMBL5260262 | 0.73 | F10 (0.59) | ALOX15F10PYGL | |
| SCHEMBL7024844 | 0.72 | FLT3 (0.62) | HRH4HRH3PDGFRBFLT3ALDH1A1 | |
| SCHEMBL7505243 | 0.71 | MEN1 (0.51) | ALOX15MEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |