Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 20/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 19/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6174165 | 1.00 | OPRM1 (0.76) | OPRM1OPRD1OPRK1 | |
| SCHEMBL6173648 | 0.94 | OPRM1 (0.84) | OPRM1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL6176266 | 0.93 | OPRM1 (0.78) | OPRM1OPRD1OPRK1 | |
| Fumaric Acid SCHEMBL6172923 | 0.92 | OPRD1 (0.71) | OPRM1OPRD1OPRK1 | |
| Fumaric Acid SCHEMBL6172924 | 0.92 | OPRD1 (0.71) | OPRM1OPRD1OPRK1 | |
| Fumaric Acid SCHEMBL6176275 | 0.89 | OPRM1 (0.77) | OPRM1OPRD1OPRK1 | |
| Fumaric Acid SCHEMBL6176280 | 0.89 | OPRM1 (0.77) | OPRM1OPRD1OPRK1 | |
| SCHEMBL8145353 | 0.86 | OPRD1 (0.74) | OPRM1OPRD1OPRK1 | |
| SCHEMBL6334592 | 0.83 | OPRD1 (0.86) | OPRM1OPRD1OPRK1 | |
| SCHEMBL6175709 | 0.82 | OPRM1 (0.82) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049676-B1 | 4- ARYL(PIPERIDIN-4-YL)] AMINOBENZAMIDES WHICH BIND TO THE DELTA-OPIOID RECEPTOR | ORTHO MCNEIL PHARM INC (US) | 2005-10-12 | — | — | EP | disclosed |
| US-6436959-B1 | DELTA-OPIOID RECEPTOR AGONISTS/ANTAGONISTS, ANALGESICS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-20 | — | — | US | disclosed |