Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174640 | 0.90 | IGF1R (0.37) | IGF1RLMNARXFP1 | |
| SCHEMBL6173243 | 0.83 | METAP2 (0.37) | IGF1RLMNARXFP1NAMPT | |
| SCHEMBL6175297 | 0.83 | LMNA (0.39) | IGF1RLMNA | |
| SCHEMBL6175175 | 0.82 | IGF1R (0.36) | IGF1RLMNA | |
| SCHEMBL6175260 | 0.82 | IGF1R (0.39) | IGF1RLMNANAMPT | |
| SCHEMBL6173182 | 0.81 | IGF1R (0.40) | IGF1RLMNAPTPRZ1 | |
| SCHEMBL6174151 | 0.81 | NAMPT (0.35) | IGF1RLMNARXFP1NAMPT | |
| SCHEMBL6171408 | 0.81 | IGF1R (0.35) | IGF1RLMNA | |
| SCHEMBL6175529 | 0.80 | IGF1R (0.37) | IGF1RLMNA | |
| SCHEMBL6175242 | 0.80 | IGF1R (0.38) | IGF1RLMNAIKBKBPTPRZ1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |