SCHEMBL6174777

SCHEMBL6174777

COC(=O)CCc1cnc(CCC(C)CNC(=O)OCc2ccccc2)o1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.41
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
HTT P42858 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CASP1 P29466 1/20 0.38
KCNA5 P22460 2/20 0.37
MAPT P10636 1/20 0.37
LMNA P02545 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
CCNE2 O96020 1/20 0.36
CCNE1 P24864 1/20 0.36
CDK2 P24941 1/20 0.36
CTSS P25774 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6178021 0.82 CYP3A4 (0.41) ATMKDM4EGAAHTTTDP1
SCHEMBL6180187 0.81 ADRB2 (0.41) ATMHTTTDP1CASP1MAPT
SCHEMBL6174773 0.74 ATM (0.49) ATMCTSS
SCHEMBL48657 0.73 L3MBTL1 (0.53) ATMHTTMAPTLMNASMN1; SMN2
SCHEMBL6940690 0.73 HTT (0.59) HTTLMNASMN1; SMN2CTSS
SCHEMBL6404796 0.73 HTT (0.59) HTTLMNASMN1; SMN2CTSS
SCHEMBL7164100 0.73 ATM (0.43) ATMMEN1KMT2ATDP1MAPT
SCHEMBL2723527 0.72 LMNA (0.52) ATMHTTLMNASMN1; SMN2L3MBTL1
SCHEMBL18086889 0.72 CTSK (0.55) HTTMAPTLMNASMN1; SMN2L3MBTL1
SCHEMBL6940875 0.72 HSD17B10 (0.50) MEN1HPGDKMT2AHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091943-B1 NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES PFIZER PROD INC (US) 2005-11-30 EP disclosed
US-6355662-B1 PEPTIDE AND NONPEPTIDES AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS PFIZER INC 2002-03-12 US disclosed
US-6306887-B1 AROMATIC UREAS, CARBAMATES AND TRIAMINONITRILES AND HETEROCYCLIC COMPOUNDS PFIZER INC 2001-10-23 US disclosed
EP-1091943-A1 NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES Pfizer Products Inc. (US) 2001-04-18 EP disclosed
WO-2000000477-A1 NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES PFIZER PRODUCTS INC. (US) 2000-01-06 WO disclosed