Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 10/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401478 | 0.82 | DRD2 (0.56) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6480903 | 0.81 | SIGMAR1 (0.64) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3454609 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31513986 | 0.78 | ALDH1A1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14410956 | 0.78 | HTR1A (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3976547 | 0.78 | ALDH1A1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1401365 | 0.78 | DRD2 (0.56) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| Ssr-150106 SCHEMBL29393331 | 0.77 | SIGMAR1 (0.48) | SIGMAR1MAPTKDM4EDRD2DRD3 | |
| Ssr-150106 SCHEMBL1385047 | 0.77 | SIGMAR1 (0.48) | SIGMAR1MAPTKDM4EDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL4589565 | 0.77 | DRD2 (0.55) | HTR1AALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209216-A1 | Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity | SANOFI-AVENTIS (FR) | 2005-09-22 | — | — | US | disclosed |
| EP-1517896-A2 | PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY | Sanofi-Aventis (FR) | 2005-03-30 | — | — | EP | disclosed |
| WO-2003106425-A2 | PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209216-A1 | Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity | TNF, TNFRSF1A, CD40 | SIGMAR1 498/4885HTR1A 397/4885ALDH1A1 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.