Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173489 | 0.92 | DPP4 (0.36) | SLC6A9GAATACR1LMNAMAPK1 | |
| SCHEMBL6176027 | 0.91 | HRH4 (0.33) | SLC6A9GAATACR1HTTALDH1A1 | |
| SCHEMBL6172665 | 0.90 | SLC6A9 (0.38) | SLC6A9LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6175279 | 0.86 | FKBP1A (0.37) | NR1H2GAACCNCCDK8HASPIN | |
| SCHEMBL6172452 | 0.85 | HTT (0.36) | SLC6A9LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6177902 | 0.85 | CYP2C9 (0.35) | GAALMNAHTTALDH1A1DPP4 | |
| SCHEMBL6171082 | 0.82 | ALDH1A1 (0.35) | GAALMNAALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6175941 | 0.82 | PTGS2 (0.39) | SLC6A9PTGS2TACR1LMNAMAPK1 | |
| SCHEMBL6172647 | 0.81 | CYP3A4 (0.35) | NR1H2GAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6173750 | 0.80 | KMT2A (0.39) | GAAPTGS2LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |