Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 5/20 | 0.50 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330776 | 0.90 | TDP1 (0.56) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL12228069 | 0.86 | TDP1 (0.50) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL330589 | 0.82 | L3MBTL1 (0.48) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL28007310 | 0.81 | TDP1 (0.52) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL27316033 | 0.80 | ALDH1A1 (0.52) | TDP1CES1CES2LMNAMAPT | |
| SCHEMBL8740775 | 0.80 | GSK3B (0.60) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL3703925 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL379271 | 0.80 | GSK3B (0.60) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL9157738 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES1CES2LMNA | |
| SCHEMBL20995296 | 0.79 | CES2 (0.61) | TDP1L3MBTL1CES1CES2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109593096-A | Tricyclic heterocyclic as BET protein inhibitor | 因赛特公司 | 2019-04-09 | — | — | CN | disclosed |
| CN-105164131-B | Tricyclic heterocycles as BET protein inhibitors | 因赛特公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-107624112-A | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof | 美国政府健康及人类服务部 | 2018-01-23 | — | — | CN | disclosed |
| CN-101918389-A | Histone deacetylase inhibitors | METHYLGENE INC | 2010-12-15 | — | — | CN | disclosed |
| EP-1291345-B1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6924276-B2 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| US-20030087924-A1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | SORENSON RODERICK JOSEPH (US) | 2003-05-08 | — | — | US | disclosed |
| EP-1291345-A1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| CN-1042639-C | Process for the preparation of low molecular weight copolymers of ethylene and at least one other 1-olefin | DSM NV (NL) | 1999-03-24 | — | — | CN | disclosed |
| US-5728911-A | CATALYTIC SOLUTION COPOLYMERIZATION OF ETHYLENE WITH POLYUNSATURATED MONOMER | DSM COPOLYMER, INC. (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1995000564-A1 | PROCESS FOR THE PREPARATION OF LOW MOLECULAR WEIGHT COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE | DSM N.V. (NL) | 1995-01-05 | — | — | WO | disclosed |
| EP-0062113-B1 | FRACTIONATION OF ALKYL CARBOXYLATE MIXTURES | THE PROCTER & GAMBLE COMPANY (US) | 1985-09-25 | — | — | EP | disclosed |
| US-4435552-A | COORDINATION CATALYST CONTAINING HALOACYL COMPOUND | STAMICARBON B.V. (NL) | 1984-03-06 | — | — | US | disclosed |
| EP-0062114-A1 | Fractionation of triglyceride mixtures | THE PROCTER & GAMBLE COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062113-A1 | Fractionation of alkyl carboxylate mixtures | THE PROCTER & GAMBLE COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0044119-A2 | Process for the preparation of copolymers of ethylene with at least one other 1-alkene | STAMICARBON B.V. (NL) | 1982-01-20 | — | — | EP | disclosed |
| US-4284580-A | ADSORPTION ON ZEOLITE | THE PROCTER & GAMBLE COMPANY (US) | 1981-08-18 | — | — | US | disclosed |
| US-4282164-A | ACCORDING TO DEGREE OF UNSATURATION USING ALUMINATED SILICA GEL ADSORBENT FOLLOWED BY DESORPTION | THE PROCTER & GAMBLE COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4277413-A | ACCORDING TO DEGREE OF UNSATURATION BY PREFERENTIAL ADSORPTION ON PERMUTITE AND USING SELECTED SOLVENTS | THE PROCTER & GAMBLE COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| US-4277412-A | PREFERENTIAL ADSORPTION BY PERMUTITE ON THE BASIS OF IODINE NUMBER AND USING SELECTED SOLVENTS | THE PROCTOR & GAMBLE COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087924-A1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | MMP13, MMP3, MMP9 | TDP1 1854/4885L3MBTL1 3063/4885CES1 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.