Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 17/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258779 | 0.84 | CSF1R (0.34) | — | |
| SCHEMBL27721400 | 0.84 | NPC1 (0.41) | GPR35 | |
| SCHEMBL1463379 | 0.84 | CXCR1 (0.49) | HIF1ANPSR1RXFP1GPR35 | |
| SCHEMBL1463507 | 0.83 | KMT2A (0.45) | — | |
| SCHEMBL1462965 | 0.82 | DDX3X (0.44) | HIF1ANPSR1RXFP1GPR35 | |
| SCHEMBL1462410 | 0.82 | RAB9A (0.51) | GPR35 | |
| SCHEMBL1464054 | 0.82 | KMT2A (0.51) | GPR35 | |
| SCHEMBL6231660 | 0.81 | ALDH1A1 (0.41) | GPR35 | |
| SCHEMBL27416023 | 0.81 | HIF1A (0.40) | HIF1ANPSR1RXFP1GPR35 | |
| SCHEMBL27449399 | 0.81 | KIF11 (0.46) | GPR35KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101287456-A | Diphenylurea derivatives useful as potassium channel activators | NEUROSEARCH AS (DK) | 2008-10-15 | — | — | CN | claimed |
| JP-2005538152-A | — | — | 2005-12-15 | — | — | JP | claimed |
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | claimed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | claimed |
| EP-1123274-A1 | SUBSTITUTED PHENYL DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2001-08-16 | — | — | EP | claimed |
| WO-2000024707-A1 | SUBSTITUTED PHENYL DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2000-05-04 | — | — | WO | claimed |
| CN-101287456-A | Diphenylurea derivatives useful as potassium channel activators | NEUROSEARCH AS (DK) | 2008-10-15 | — | — | CN | disclosed |
| WO-2004012733-A9 | COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES RESPONSIVE TO ANTIANGIOGENETIC THERAPY | NEUROSEARCH AS (DK) | 2005-03-10 | — | — | WO | disclosed |
| WO-2002039987-A2 | USE OF MALARIA PARASITE ANION CHANNEL BLOCKERS FOR TREATING MALARIA | NEUROSEARCH A/S (DK) | 2002-05-23 | — | — | WO | disclosed |