Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGES | O14684 | 4/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188857 | 1.00 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL8396539 | 1.00 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6186052 | 0.74 | ALOX5 (0.58) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6206054 | 0.72 | ALOX5 (0.69) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL8394211 | 0.72 | ALOX5 (0.37) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL6497004 | 0.67 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495009 | 0.67 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL8398200 | 0.66 | ALOX5 (0.51) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6498829 | 0.66 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL7002805 | 0.65 | PTGES (0.78) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804437-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 2005-09-14 | — | — | EP | disclosed |