Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30216205 | 0.72 | L3MBTL1 (0.43) | ALDH1A1MEN1KMT2AL3MBTL1HPGD | |
| SCHEMBL29191896 | 0.72 | L3MBTL1 (0.43) | ALDH1A1MEN1KMT2AL3MBTL1HPGD | |
| SCHEMBL12797297 | 0.70 | FBP1 (0.63) | ALDH1A1ADORA1MAPTKDM4EFBP1 | |
| SCHEMBL15174607 | 0.70 | MAPT (0.46) | ALDH1A1MEN1KMT2AL3MBTL1HPGD | |
| SCHEMBL598138 | 0.67 | TDP1 (0.61) | L3MBTL1TDP1 | |
| SCHEMBL15174702 | 0.67 | ADORA1 (0.63) | ALDH1A1ADORA1MAPTKDM4EFBP1 | |
| SCHEMBL595453 | 0.65 | KDM4E (0.57) | ALDH1A1MEN1KMT2AL3MBTL1HPGD | |
| SCHEMBL30903625 | 0.65 | APP (0.71) | ALDH1A1MEN1KMT2AHPGDMAPT | |
| SCHEMBL15414023 | 0.65 | APP (0.71) | ALDH1A1MEN1KMT2AHPGDMAPT | |
| SCHEMBL31390879 | 0.65 | ADORA1 (0.67) | ALDH1A1ADORA1MAPTKDM4EFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183247-B1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA GMBH (DE) | 2005-05-25 | — | — | EP | disclosed |
| EP-1156805-B1 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR MANUFACTURING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | AVENTIS PHARMA GMBH (DE) | 2004-08-11 | — | — | EP | disclosed |
| EP-1183247-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6329407-B1 | ANOREXOGENIC AGENTS | AVENTISPHARMA DEUTSCHLAND GMBH (DE) | 2001-12-11 | — | — | US | disclosed |
| EP-1156805-A2 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | Aventis Pharma Deutschland GmbH (DE) | 2001-11-28 | — | — | EP | disclosed |
| US-6187801-B1 | 6-CHLORO-2-METHYL-8H-INDENO(1,2-D)-THIAZOLE HYDROCHLORIDE, FOR EXAMPLE; ADMINISTERING TO TREAT OBESITY, DIABETES; ANORECTICS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-02-13 | — | — | US | disclosed |
| WO-2000051579-A2 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000051997-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |