SCHEMBL595453

SCHEMBL595453

Brc1ccc2sc(-c3ccccc3)nc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.57
RAB9A P51151 8/20 0.55
NFKB1 P19838 7/20 0.55
NFKB2 Q00653 7/20 0.55
RELA Q04206 7/20 0.55
NPC1 O15118 7/20 0.55
HPGD P15428 3/20 0.55
STAT1 P42224 1/20 0.55
APP P05067 4/20 0.54
SMN1; SMN2 Q16637 6/20 0.53
MAPT P10636 5/20 0.53
GAA P10253 4/20 0.53
ALDH1A1 P00352 4/20 0.53
PKM P14618 3/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
GLA P06280 2/20 0.53
POLB P06746 2/20 0.51
GFER P55789 1/20 0.51
LMNA P02545 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10989659 0.89 APP (0.61) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL15414023 0.86 APP (0.71) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL30903625 0.86 APP (0.71) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL25752044 0.83 APP (0.55) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL19984988 0.83 APP (0.77) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL3187010 0.81 KDM4E (0.68) KDM4ERAB9ANFKB1NFKB2RELA
Dimethylamine SCHEMBL2524428 0.81 APP (0.72) KDM4ENFKB1NFKB2RELAHPGD
SCHEMBL17404415 0.80 KDM4E (0.66) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL34460069 0.79 TNF (0.49) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL2914054 0.79 APP (0.66) KDM4ERAB9ANFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240246953-A1 ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND LG DISPLAY CO., LTD. (KR) 2024-07-25 US disclosed
US-20240237519-A1 ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND LG DISPLAY CO., LTD. (KR) 2024-07-11 US disclosed
EP-4063368-B1 NITROGEN-CONTAINING COMPOUND AND ELECTRONIC ELEMENT COMPRISING SAME, AND ELECTRONIC APPARATUS SHAANXI LIGHTE OPTOELECTRONICS MAT CO LTD (CN) 2024-06-26 EP disclosed
EP-4389851-A1 ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND LG Display Co., Ltd. (KR) 2024-06-26 EP disclosed
CN-118239943-A Organic compound, organic light emitting diode having the same, and organic light emitting device 乐金显示有限公司 2024-06-25 CN disclosed
CN-118239944-A Organic compound, organic light emitting diode having the same, and organic light emitting device 乐金显示有限公司 2024-06-25 CN disclosed
US-20230200233-A1 COMPOSITION, ELECTRONIC COMPOMENT AND ELECTRONIC DEVICE CONTAINING THE COMPOSITION SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2023-06-22 US disclosed
US-20230200233-A1 COMPOSITION, ELECTRONIC COMPOMENT AND ELECTRONIC DEVICE CONTAINING THE COMPOSITION SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2023-06-22 US disclosed
US-20230142329-A1 ORGANIC LIGHT EMITTING ELEMENT LG DISPLAY CO., LTD. (KR) 2023-05-11 US disclosed
US-20230142329-A1 ORGANIC LIGHT EMITTING ELEMENT LG DISPLAY CO., LTD. (KR) 2023-05-11 US disclosed
US-20090274698-A1 Combination anti-cancer therapy OSI PHARMACEUTICALS, INC. 2009-11-05 US disclosed
US-20090163468-A1 Fused Bicyclic mTor Inhibitors OSI PHARMACEUTICALS, INC. 2009-06-25 US disclosed
WO-2009008992-A2 COMBINATION ANTI-CANCER THERAPY COMPRISING AN INHIBITOR OF BOTH MTORC1 AND MT0RC2 OSI PHARMACEUTICALS INC. (US) 2009-01-15 WO disclosed
EP-1996193-A2 COMBINED TREATMENT WITH AN EGFR KINASE INHIBITOR AND AN AGENT THAT SENSITIZES TUMOR CELLS TO THE EFFECTS OF EGFR KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2008-12-03 EP disclosed
CN-101316845-A Fused bicyclic mTOR inhibitors OSI PHARM INC (US) 2008-12-03 CN disclosed
EP-1951724-A2 FUSED BICYCLIC mTOR INHIBITORS OSI Pharmaceuticals, Inc. (US) 2008-08-06 EP disclosed
US-20070280928-A1 Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors OSI PHARMACEUTICALS, INC. 2007-12-06 US disclosed
WO-2007106503-A2 COMBINED TREATMENT WITH AN EGFR KINASE INHIBITOR AND AN AGENT THAT SENSITIZES TUMOR CELLS TO THE EFFECTS OF EGFR KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-09-20 WO disclosed
WO-2007061737-A2 FUSED BICYCLIC mTOR INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-05-31 WO disclosed
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer OSI PHARMACEUTICALS, INC. 2007-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090163468-A1 Fused Bicyclic mTor Inhibitors MTOR, RICTOR, MAPKAP1 KDM4E 1344/4885RAB9A 223/4885NFKB1 2406/4885
US-20090274698-A1 Combination anti-cancer therapy MTOR, RICTOR, AKT1 KDM4E 1612/4885RAB9A 720/4885NFKB1 1500/4885
US-20240246953-A1 ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND TELO2, ARNT, TYR KDM4E 1580/4885RAB9A 4231/4885NFKB1 2667/4885
US-20070280928-A1 Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors EGFR, ERBB2, RICTOR KDM4E 3387/4885RAB9A 564/4885NFKB1 2340/4885
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer MTOR, MAPKAP1, RPS6KA1 KDM4E 1473/4885RAB9A 1191/4885NFKB1 805/4885
US-20240237519-A1 ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND NLRP3, NLRP1, TYR KDM4E 1611/4885RAB9A 4296/4885NFKB1 1419/4885
US-20230142329-A1 ORGANIC LIGHT EMITTING ELEMENT L3MBTL3, L3MBTL4, CRY2 KDM4E 1272/4885RAB9A 3651/4885NFKB1 1568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.