Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.36 |
| ▸ | ACHE | P22303 | 5/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193996 | 0.83 | PDK2 (0.39) | NR4A2PDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL5242745 | 0.81 | SLC6A9 (0.45) | PDK2ALDH1A1KDM4EBCHEACHE | |
| SCHEMBL5241856 | 0.81 | HTR6 (0.47) | PDK2ALDH1A1KDM4EBCHEACHE | |
| SCHEMBL5241520 | 0.79 | PDK2 (0.39) | PDK2ALDH1A1KDM4EBCHEACHE | |
| SCHEMBL5242280 | 0.79 | HTR6 (0.41) | PDK2ALDH1A1KDM4EBCHEACHE | |
| SCHEMBL5243442 | 0.78 | BCHE (0.55) | PDK2ALDH1A1KDM4EBCHERBP4 | |
| SCHEMBL3853276 | 0.76 | HTR1A (0.48) | PDK2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL7004599 | 0.75 | ALDH1A1 (0.62) | NR4A2ALDH1A1HPGDLMNAHTT | |
| SCHEMBL6195740 | 0.74 | F2 (0.37) | PDK2ALDH1A1KDM4EBCHERBP4 | |
| SCHEMBL15076180 | 0.73 | RBP4 (0.54) | PDK2ALDH1A1KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569638-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004050085-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |