Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236846 | 0.75 | ALOX5 (0.35) | ALOX5ALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL4849289 | 0.73 | ALDH1A1 (0.33) | ALOX5ALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL3624225 | 0.68 | CYP2B6 (0.40) | ALOX5ALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL4037430 | 0.67 | ALDH1A1 (0.54) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL2543830 | 0.65 | ALDH1A1 (0.57) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL4039124 | 0.65 | ALDH1A1 (0.33) | ALOX5ALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL5363332 | 0.64 | ALOX5 (0.34) | ALOX5ALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL6618016 | 0.63 | ALDH1A1 (0.39) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL14036308 | 0.61 | MCL1 (0.53) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL29628903 | 0.61 | MCL1 (0.53) | ALDH1A1HPGDTSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1315838-C | 1-oxa-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA D D (HR) | 2007-05-16 | — | — | CN | disclosed |
| US-20050209214-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | disclosed |
| CN-1665821-A | 1-oxa-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA D D (HR) | 2005-09-07 | — | — | CN | disclosed |
| US-20050148577-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| EP-1506204-A2 | 1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097649-A2 | 1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148577-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1B, IL1A | ALOX5 157/4885ALDH1A1 41/4885HPGD 141/4885 |
| US-20050209214-A1 | 1-oxa-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | TNF, IL1B, IL1A | ALOX5 160/4885ALDH1A1 43/4885HPGD 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.