Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543830 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL28336706 | 0.87 | HPRT1 (0.56) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL57494 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL27587100 | 0.84 | CYP11B1 (0.50) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL12520786 | 0.84 | CYP11B1 (0.58) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL6429399 | 0.84 | TNF (0.60) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL14036308 | 0.83 | MCL1 (0.53) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL29628903 | 0.83 | MCL1 (0.53) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL4444809 | 0.83 | HPRT1 (0.56) | ALDH1A1HSD17B10HPGDHIF1ATSHR | |
| SCHEMBL1527419 | 0.81 | HPRT1 (0.54) | ALDH1A1HSD17B10HPGDHIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160271143-A1 | ESTROGEN RECEPTOR MODULATORS FOR REDUCING BODY WEIGHT | ROSSCREENING INC (US) | 2016-09-22 | — | — | US | claimed |
| US-20140378424-A1 | ESTROGEN RECEPTOR MODULATORS FOR REDUCING BODY WEIGHT | ROSSCREENING INC (US) | 2014-12-25 | — | — | US | claimed |
| WO-2013102207-A1 | ESTROGEN RECEPTOR MODULATORS FOR REDUCING BODY WEIGHT | ROSSCREENING, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | claimed |
| US-20060111340-A1 | 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-05-25 | — | — | US | claimed |
| EP-1492797-B1 | 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF | PLIVA ISTRAZIVACKI INST D O O (HR) | 2006-03-15 | — | — | EP | claimed |
| US-20050148576-A1 | 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | claimed |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-06-16 | — | — | US | claimed |
| US-20050107350-A1 | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | US | claimed |
| EP-1509532-A1 | 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-03-02 | — | — | EP | claimed |
| EP-1492797-A1 | 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2005-01-05 | — | — | EP | claimed |
| WO-2003099827-A1 | 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-12-04 | — | — | WO | claimed |
| WO-2003084964-A1 | 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-10-16 | — | — | WO | claimed |
| US-20030153750-A1 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors | PLIVA FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO | 2003-08-14 | — | — | US | claimed |
| EP-1284977-A1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2003-02-26 | — | — | EP | claimed |
| WO-2001087890-A1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | PLIVA, FARMACEUTSKA INDUSTRIJA, DIONIKO DRUSTVO (HR) | 2001-11-22 | — | — | WO | claimed |
| CN-110290816-A | For targeting the radioactive marking material of application | 澳大利亚国立大学 | 2019-09-27 | — | — | CN | disclosed |
| CN-104411667-B | The manufacture method of 1,3,3,3-tetrafluoropropene | 中央硝子株式会社 | 2016-11-09 | — | — | CN | disclosed |
| WO-2001087890-A1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | PLIVA, FARMACEUTSKA INDUSTRIJA, DIONIKO DRUSTVO (HR) | 2001-11-22 | — | — | WO | disclosed |
| EP-0035903-B1 | DIBENZOCYCLOHEPTENYLIDENES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153750-A1 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors | TNF, IL1B, IL1A | ALDH1A1 48/4885HSD17B10 769/4885HPGD 62/4885 |
| US-20050148576-A1 | 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | TNF, IL1A, IL1B | ALDH1A1 42/4885HSD17B10 1176/4885HPGD 183/4885 |
| US-20060111340-A1 | 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | IL1A, TNF, IL1B | ALDH1A1 40/4885HSD17B10 1552/4885HPGD 156/4885 |
| US-20050107350-A1 | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith | PTGS2, PTGES2, PTGS1 | ALDH1A1 1192/4885HSD17B10 493/4885HPGD 14/4885 |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | TNF, IL1A, IL1B | ALDH1A1 34/4885HSD17B10 1253/4885HPGD 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.