Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13916682 | 0.87 | KDM4E (0.69) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL13916685 | 0.85 | KDM4E (0.67) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL27306910 | 0.77 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL862261 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL21980601 | 0.74 | PDGFRB (0.50) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL28392846 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL6200788 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL15233270 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL4882909 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1LMNAPDGFRBKIT | |
| SCHEMBL10642137 | 0.73 | ALOX15 (0.59) | KDM4EALDH1A1LMNAPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228072-B1 | PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION, PURIFICATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME | YISSUM RES DEV CO (IL) | 2005-09-28 | — | — | EP | disclosed |
| US-20040132725-A1 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same | LEVITZKI ALEXANDER (IL) | 2004-07-08 | — | — | US | disclosed |
| US-6673798-B2 | PLATELET DERIVED GROWTH FACTORS (PDGF); 1,2-DIMETHYL-6-(2-THIOPHENE)IMIDAZOLO(5,4-G)QUINOXALINE PREPARATIONS FOR EXAMPLE; USE TREATING PROLIFERATIVE MALIGNANT AND NON-MALIGNANT DISEASES; STENTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-01-06 | — | — | US | disclosed |
| EP-1228072-A4 | PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION, PURIFICATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME | YISSUM RES DEV CO (IL) | 2003-05-07 | — | — | EP | disclosed |
| EP-1228072-A1 | PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION, PURIFICATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME | Yissum Research Development Company of the Hebrew University of Jerusalem (IL) | 2002-08-07 | — | — | EP | disclosed |
| US-6358954-B1 | IMIDAZO(4,5-G)QUINOXALINE DERIVATIVES; ANTITUMOR, ANTICARCINOGENIC AND ANTIPROLIFERATIVE AGENTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2002-03-19 | — | — | US | disclosed |
| US-20020028817-A1 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM | 2002-03-07 | — | — | US | disclosed |
| WO-2001034607-A1 | PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION, PURIFICATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028817-A1 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same | PDGFRB, PDGFRA, PDGFA | KDM4E 2256/4885ALDH1A1 4292/4885LMNA 3811/4885 |
| US-20040132725-A1 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same | PDGFRB, PDGFRA, PDGFA | KDM4E 2256/4885ALDH1A1 4292/4885LMNA 3811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.