Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE6C | P51160 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201142 | 0.86 | CDK1 (0.46) | CDK2CCNE1CCNE2CDK5CCNT1 | |
| SCHEMBL6202208 | 0.86 | CDK1 (0.33) | CDK2CCNE1CCNE2CDK5CDK1 | |
| SCHEMBL6202508 | 0.85 | LCK (0.30) | CDK2CCNE1CCNE2CDK5CDK1 | |
| SCHEMBL6204605 | 0.84 | TSHR (0.32) | CDK2CCNE1CCNE2CDK5CDK1 | |
| SCHEMBL6203171 | 0.82 | CCNE1 (0.37) | CDK2CCNE1CCNE2CDK5AURKA | |
| SCHEMBL6204524 | 0.81 | CCNE2 (0.34) | CDK2CCNE1CCNE2CDK5CCNT1 | |
| SCHEMBL6204274 | 0.81 | CCR4 (0.33) | CDK2CCNE1CCNE2 | |
| SCHEMBL6204529 | 0.80 | CCNE2 (0.44) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL6203855 | 0.80 | CCNE1 (0.34) | CDK2CCNE1CCNE2CDK5CCNT1 | |
| SCHEMBL6203460 | 0.78 | MTOR (0.32) | CDK2CCNE1CCNE2CDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |