Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.38 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE6C | P51160 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203326 | 0.86 | CDK2 (0.38) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6203806 | 0.86 | STAT3 (0.36) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6204529 | 0.85 | CCNE2 (0.44) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6205328 | 0.84 | PARP1 (0.36) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6202208 | 0.84 | CDK1 (0.33) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6204524 | 0.83 | CCNE2 (0.34) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6203858 | 0.82 | LMNA (0.35) | CDK1CDK5CCNT1CDK9 | |
| SCHEMBL6204605 | 0.81 | TSHR (0.32) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6202508 | 0.81 | LCK (0.30) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL6205469 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |