Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 8/20 | 0.34 |
| ▸ | CDK2 | P24941 | 8/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | PDE6C | P51160 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204274 | 0.87 | CCR4 (0.33) | CCNE1CDK2CCNE2 | |
| SCHEMBL6203460 | 0.86 | MTOR (0.32) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL6204811 | 0.83 | PRUNE1 (0.32) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL6203326 | 0.80 | CDK2 (0.38) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL6201142 | 0.79 | CDK1 (0.46) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL6204605 | 0.79 | TSHR (0.32) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL3445281 | 0.78 | CDK2 (0.38) | CCNE1CDK2CCNE2CCNT1CDK9 | |
| SCHEMBL3445936 | 0.78 | CDK1 (0.41) | CCNE1CDK2CCNE2CCNT1CDK9 | |
| SCHEMBL6202208 | 0.78 | CDK1 (0.33) | CCNE1CDK2PDE5APDE4DPDE6C | |
| SCHEMBL6205419 | 0.77 | CCNE1 (0.36) | CCNE1CDK2PDE5APDE4DPDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534681-A1 | SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004002960-A1 | SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-01-08 | — | — | WO | disclosed |