SCHEMBL620359

SCHEMBL620359

CCOC(=O)c1cnc2ccc(OC)cc2c1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.63
ALDH1A1 P00352 6/20 0.63
HPGD P15428 4/20 0.63
LMNA P02545 4/20 0.63
SMN1; SMN2 Q16637 3/20 0.63
KDM4E B2RXH2 2/20 0.63
TDP1 Q9NUW8 1/20 0.63
NMT1 P30419 2/20 0.62
TP53 P04637 3/20 0.61
KMT2A Q03164 3/20 0.58
NPSR1 Q6W5P4 2/20 0.57
HTT P42858 1/20 0.57
CLK1 P49759 1/20 0.57
GAA P10253 2/20 0.55
MEN1 O00255 2/20 0.55
THRB P10828 1/20 0.55
SLC2A1 P11166 1/20 0.55
RAB9A P51151 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
NMT2 O60551 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31603107 1.00 MAPT (0.63) MAPTALDH1A1HPGDLMNASMN1; SMN2
Butane SCHEMBL3825261 0.97 MAPT (0.61) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL30855071 0.95 MAPT (0.61) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL29896399 0.93 MAPT (0.55) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL18285426 0.93 MAPT (0.55) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL618410 0.91 MAPT (0.62) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL1040706 0.90 MAPT (0.54) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL620990 0.88 MAPT (0.53) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL620385 0.88 NMT1 (0.53) MAPTALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL6197990 0.86 TP53 (0.63) MAPTALDH1A1HPGDLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR UNIV JIMEI (CN) 2025-09-04 US claimed
WO-2025107568-A1 USE OF KYNURENIC ACID IN RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARING XOD INHIBITOR 集美大学 2025-05-30 WO claimed
CN-117883445-A Application of hyperuricemia resistance of canine uric acid and structural analogue thereof in preparation of XOD inhibitor 集美大学 2024-04-16 CN claimed
EP-4155300-B1 SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS US HEALTH (US) 2026-02-11 EP disclosed
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR UNIV JIMEI (CN) 2025-09-04 US disclosed
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP disclosed
WO-2025107568-A1 USE OF KYNURENIC ACID IN RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARING XOD INHIBITOR 集美大学 2025-05-30 WO disclosed
WO-2025111318-A1 SOMATOSTATIN SUBTYPE RECEPTOR 3 (SSTR3) AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2025-05-30 WO disclosed
CN-117883445-A Application of hyperuricemia resistance of canine uric acid and structural analogue thereof in preparation of XOD inhibitor 集美大学 2024-04-16 CN disclosed
EP-3704102-B1 SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS US HEALTH (US) 2024-02-28 EP disclosed
US-11795177-B2 Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-10-24 US disclosed
WO-2003018021-A1 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS AMGEN INC. (US) 2003-03-06 WO disclosed
EP-1266888-A1 QUINOLINE DERIVATIVES AND MEDICINAL USE THEREOF Mitsui Chemicals, Inc. (JP) 2002-12-18 EP disclosed
EP-1042295-A1 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2000-10-11 EP disclosed
US-6093732-A PREVENT HERPESVIRAL INFECTIONS, PARTICULARLY, HUMAN CYTOMEGALOVIRAL INFECTION PHARMACIA & UPJOHN COMPANY (US) 2000-07-25 US disclosed
WO-1999032450-A1 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-01 WO disclosed
EP-0045375-B1 PROCESS FOR THE PREPARATION OF QUINOLINES, NAPHTHYRIDINES AND OTHER NITROGEN-BI-HETEROCYCLIC COMPOUNDS HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) 1985-01-23 EP disclosed
US-4450166-A N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anxiolytic activity ROUSSEL UCLAF (FR) 1984-05-22 US disclosed
US-4380632-A HYDROLYSIS OF THE CARBALKOXY DERIVATIVE BY WATER USING AN ACID CATALYST; PRESSURIZATION; DISTILLATION; NEUTRALIZATION; DECARBOXYLATION DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1983-04-19 US disclosed
US-4343804-A 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds A. H. ROBINS COMPANY, INC. (US) 1982-08-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR XDH, DAO, KMO MAPT 4081/4885ALDH1A1 635/4885HPGD 93/4885
US-11795177-B2 Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors ALDH1A1, ALDH1A2, ALDH1B1 MAPT 3750/4885ALDH1A1 1/4885HPGD 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.