Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.39 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.39 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046392 | 0.84 | HRH3 (0.48) | ALDH1A1BCHEACHEHRH3TSHR | |
| SCHEMBL7237973 | 0.82 | KDM4E (0.46) | ALDH1A1KDM4EBCHEACHEHRH3 | |
| SCHEMBL8345386 | 0.75 | L3MBTL1 (0.41) | ALDH1A1KDM4EBCHEACHEHRH3 | |
| SCHEMBL10083411 | 0.75 | ALDH1A1 (0.52) | ALDH1A1KDM4EBCHEACHEHRH3 | |
| SCHEMBL15105581 | 0.74 | BCHE (0.49) | ALDH1A1KDM4EBCHEACHEPTGS2 | |
| SCHEMBL6394314 | 0.74 | PTGS2 (0.57) | BCHEACHEPTGS2CHRM2CHRM1 | |
| SCHEMBL13237042 | 0.73 | ACHE (0.49) | ALDH1A1BCHEACHETSHRATM | |
| SCHEMBL10065870 | 0.71 | PYCR1 (0.55) | ALDH1A1KDM4EBCHEACHEHRH3 | |
| SCHEMBL25222593 | 0.71 | ALDH1A1 (0.46) | ALDH1A1KDM4EBCHEACHETSHR | |
| SCHEMBL3153586 | 0.70 | MAPT (0.48) | ALDH1A1KDM4EBCHEACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |