Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204808 | 0.86 | PRUNE1 (0.37) | PRUNE1TSHRHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL6205414 | 0.85 | HMGCR (0.32) | PRUNE1 | |
| SCHEMBL6203855 | 0.83 | CCNE1 (0.34) | PRUNE1TSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL6203495 | 0.80 | PRUNE1 (0.35) | PRUNE1CCNE1CDK2PDE5APDE6C | |
| SCHEMBL6203171 | 0.79 | CCNE1 (0.37) | CCNE1CDK2 | |
| SCHEMBL6202760 | 0.79 | CDK1 (0.40) | PRUNE1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL6204719 | 0.78 | PGK1 (0.33) | — | |
| SCHEMBL3444717 | 0.76 | CDK2 (0.52) | TSHRTP53SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3445281 | 0.75 | CDK2 (0.38) | HSD17B10ALDH1A1MAPTGAANPC1 | |
| SCHEMBL3445936 | 0.74 | CDK1 (0.41) | MAPTRAB9APKMKDM4ECCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |