Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203635 | 0.81 | PNMT (0.58) | IDO1TSHRPNMTMAPT | |
| SCHEMBL6205217 | 0.75 | IDO1 (0.39) | IDO1NR3C1PGRNR3C2TSHR | |
| SCHEMBL6203919 | 0.75 | PNMT (0.55) | IDO1TSHRPNMTTACR1 | |
| SCHEMBL6203594 | 0.71 | MAOA (0.40) | L3MBTL1MAPTDAO | |
| SCHEMBL5018736 | 0.70 | PNMT (0.43) | IDO1NR3C1PGRNR3C2TSHR | |
| SCHEMBL1357677 | 0.70 | TAAR1 (0.46) | EPHX1 | |
| SCHEMBL6204797 | 0.69 | SLC6A4 (0.38) | IDO1NR3C1NR3C2EPHX1MAPT | |
| SCHEMBL8430281 | 0.68 | ALDH1A1 (0.47) | IDO1L3MBTL1CARM1PRMT6 | |
| SCHEMBL5751477 | 0.68 | MDM2 (0.44) | IDO1NR3C1PGRNR3C2TSHR | |
| SCHEMBL6204601 | 0.68 | PKM (0.41) | IDO1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |