Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27606231 | 0.84 | PNMT (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6204601 | 0.78 | PKM (0.41) | MEN1KMT2AL3MBTL1LDHASMN1; SMN2 | |
| SCHEMBL6204804 | 0.77 | PSMB5 (0.38) | MEN1HTTKMT2APSMB5PSMB8 | |
| SCHEMBL6205345 | 0.76 | IDO1 (0.47) | CTSBMAPTALDH1A1 | |
| SCHEMBL6203594 | 0.76 | MAOA (0.40) | HTTMAPTL3MBTL1LDHAALDH1A1 | |
| SCHEMBL6203919 | 0.76 | PNMT (0.55) | MEN1KMT2ALMNASMN1; SMN2 | |
| Bromide SCHEMBL27951844 | 0.74 | PSMB5 (0.38) | MEN1HTTKMT2APSMB5PSMB8 | |
| SCHEMBL11781933 | 0.74 | PSMB5 (0.38) | MEN1HTTKMT2APSMB5PSMB8 | |
| SCHEMBL6788119 | 0.73 | PSMB5 (0.38) | PSMB5PSMB8CTSBCNR1LDHA | |
| SCHEMBL7562470 | 0.73 | GABRA1 (0.50) | MEN1KMT2APSMB5PSMB8CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |