Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361668 | 0.87 | ALDH1A1 (0.49) | DRD2DRD3KDM1AMAOAMAOB | |
| SCHEMBL15883544 | 0.83 | KMT2A (0.51) | DRD2DRD3GRIN2BADRA1AALDH1A1 | |
| SCHEMBL22435539 | 0.81 | ACHE (0.45) | DRD2DRD3KDM1AMAOAMAOB | |
| SCHEMBL227574 | 0.80 | DRD2 (0.50) | DRD2DRD3KDM1AMAOAMAOB | |
| SCHEMBL19428987 | 0.79 | CYP26A1 (0.52) | DRD2DRD3CA1CA2ACHE | |
| SCHEMBL6491129 | 0.79 | SIGMAR1 (0.74) | DRD2SIGMAR1CYP26A1CYP19A1ADRA1A | |
| SCHEMBL16547295 | 0.77 | ALOX12 (0.46) | KDM1AMAOAMAOBCYP19A1ALDH1A1 | |
| SCHEMBL16547296 | 0.77 | DRD2 (0.46) | DRD2DRD3KDM1AMAOAMAOB | |
| SCHEMBL2001983 | 0.77 | CYP19A1 (0.42) | DRD2DRD3CA1CA2ACHE | |
| SCHEMBL226728 | 0.77 | DRD2 (0.49) | DRD2DRD3CA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583759-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063191-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2004-07-29 | — | — | WO | disclosed |