Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DBH | P09172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204800 | 0.79 | ALOX15 (0.38) | SLC6A4SLC6A2MAOBHTR2AKCNH2 | |
| SCHEMBL6205165 | 0.78 | PPARG (0.43) | SLC6A4SLC6A2MAOBIDO1LMNA | |
| SCHEMBL5018843 | 0.75 | SLC6A2 (0.45) | SLC6A4SLC6A2MAOBTP53HTT | |
| SCHEMBL6203919 | 0.73 | PNMT (0.55) | SLC6A4SLC6A2KCNH2IDO1MEN1 | |
| SCHEMBL30102510 | 0.72 | HTR2A (0.51) | SLC6A4HTR2AKCNH2TP53POLB | |
| SCHEMBL257058 | 0.72 | HTR2A (0.51) | SLC6A4HTR2AKCNH2TP53POLB | |
| SCHEMBL13692464 | 0.72 | HTR2A (0.54) | SLC6A4SLC6A2HTR2ATP53HTT | |
| SCHEMBL6203635 | 0.71 | PNMT (0.58) | TP53POLBIDO1MAPT | |
| SCHEMBL6202920 | 0.71 | PNMT (0.47) | SLC6A4SLC6A2POLBIDO1LMNA | |
| SCHEMBL27963927 | 0.71 | ALDH1A1 (0.40) | SLC6A4SLC6A2MAOBTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |