Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24876469 | 0.83 | NR3C1 (0.38) | SLC6A4KMT2AHTR2AKCNH2 | |
| SCHEMBL6204797 | 0.79 | SLC6A4 (0.38) | ALOX15ALOX12SLC6A4SLC6A2HTT | |
| SCHEMBL6205167 | 0.78 | PPARG (0.43) | SLC6A4SLC6A2LMNAIDO1ALDH1A1 | |
| SCHEMBL13692464 | 0.76 | HTR2A (0.54) | ALOX15ALOX12SLC6A4SLC6A2HTT | |
| SCHEMBL8886789 | 0.76 | IDO1 (0.41) | ALOX15ALOX12SLC6A4SLC6A2CYP3A4 | |
| SCHEMBL5018843 | 0.75 | SLC6A2 (0.45) | ALOX15ALOX12SLC6A4SLC6A2CYP3A4 | |
| SCHEMBL23552458 | 0.74 | MRGPRX4 (0.44) | ALOX15CYP3A4HTTMEN1HPGD | |
| SCHEMBL6203922 | 0.73 | PNMT (0.55) | ALOX15SLC6A4SLC6A2MEN1IDO1 | |
| SCHEMBL6202922 | 0.71 | PNMT (0.47) | SLC6A4SLC6A2CYP3A4IDO1SMN1; SMN2 | |
| SCHEMBL6203638 | 0.71 | PNMT (0.58) | CYP3A4IDO1MAOBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |